The Neuroinflammation Research Laboratory at UBC
Join Our Team: The Neuroinflammation Research Laboratory at UBC
Positions: Post-doctoral fellow and Graduate student
With support from funding agencies as well as privately funded initiatives, the Neuroinflammation Research Lab is growing. We are expanding our research efforts and are looking for committed team players interested in making a difference in health research and the lives of individuals living with neurodegenerative disorders including MS.
Focus project areas:
- Imaging and therapeutic strategies in preclinical models of neuroinflammatory disorders
- Limiting inflammation and activation of the blood-brain barrier
- Biomarker analyses in patient cohorts
- Environmental influence upon inflammatory and neuroprotective proteins and processes relevant to multiple sclerosis and other neurodegenerative disorders.
Graduate Program in Pathology & Laboratory Medicine or Graduate Program in Neuroscience: Candidates for a graduate student position can expect to gain training and expertise in a number of the techniques below. Possible projects will focus on:
1. Immune reactivities to lipid and myelin antigens in MS patient samples compared to healthy volunteers and correlates with MRI findings in diffusely abnormal white matter – immunology focus
2. Neuroprotection: regulation of environmentally-regulated factors that are expressed in the periphery and the CNS with relevance to repair and regeneration – neuroinflammation and neuroscience focus
3. Mouse models of progressive MS: analyses of clinical and histological disease with genetic sequencing and analyses in murine models carrying human mutations relevant to progressive MS in families – neuroinflammation and genetics focus
4. Testing of novel therapeutics for efficacy in animal models of MS relevant to inflammation, demyelination and neurodegeneration – neurobiology and immunology focus
Post-doctoral fellowship in Pathology & Laboratory Medicine: Candidates with expertise in neuroscience/immunology related cell culture, molecular biology, murine preclinical and behavioural models are encouraged to apply for the Post-Doctoral position, where some advanced training prior to joining the laboratory are requisite. The successful candidate will undertake a research project aimed to examine factors that regulate neuroprotective proteins both in the peripheral immune and within the central nervous system.
Training & expectations: Major areas of focus will include inflammatory mediators, oxidative stress, environmental stressors, immune populations, neurodegeneration and repair. While graduate students accepted for the position can expect to receive training and proficiency in a number of the following, the candidate for a PDF position should have a solid understanding and demonstrated proficiency in several of the following:
- Cell culture and aseptic technique, preferably involving both isolation and maintenance of rodent primary cultures as well as cell lines.
- Aseptic technique and experience with human blood handling for the isolation of PBMC and subsequent culture/assay
- Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques, including many of the following:
RNA/DNA isolation, quantitative PCR, transfection, siRNA knockdown and cDNA construct knockin, flow cytometry, immunohisto- and cytochemistry on cells as well as frozen and formalin-fixed, paraffin embedded tissues, fluorescence and light microscopy; conventional and/or confocal; ELISA, protein isolation and western blotting;
- Comprehensive understanding of experimental design and assay optimization is important along with ability to work well with others and to work independently.
- Willingness to work with small rodents is essential. Able to carry out and oversee procedures involving small rodents including immunization/injections, necropsy, blood sampling, and minor surgical procedures involved in animal surgery; applicants with experience in pre-clinical models of neurodegenerative diseases including MS are especially encouraged to apply.
- Maintenance/monitoring of colonies of transgenic animals, including colony breeding, screening and management.
- Excellent verbal and written communication skills including manuscript preparation, data presentation and discussion in group settings and at meetings and/or conferences
Studies will span basic cell analyses through to more complex models and ultimately translation of these findings to human systems and disease.
Interested candidates should send a statement of research interests and an updated CV to firstname.lastname@example.org. Inquiries will be reviewed on a rotating basic until positions have been filled.
Graduate position start date: September 2018 or January 2019
Post Doctoral fellow start date: September 2018 or earlier; position may be held for an outstanding candidate