We are growing and looking for a few great folks to join our team! We are expanding our research efforts and are looking for committed team players interested in making a difference in the lives of individuals living with neurodegenerative disorders including MS. Studies will span basic cell analyses through to more complex models and ultimately translation of these findings to human systems and disorders.

Focus project areas:

• Imaging and therapeutic strategies in preclinical models of neuroinflammatory disorders
• Biomarker analyses in relevant clinical groups
• Environmental influence upon inflammatory and neuroprotective proteins and processes relevant to multiple sclerosis and other neurodegenerative disorders 

Post-Doctoral Fellow – Start Fall/Winter 2026

With support from funding agencies as well as privately funded initiatives our group is growing. We are expanding our research efforts and are looking for committed team players interested in making a difference in health research and the lives of individuals living with neurodegenerative disorders including MS.

We are seeking a motivated Postdoctoral Fellow to step into a scientific leadership role on a CIHR-funded project. This study explores a preclinical model of primary progressive MS based on an Nr1h3 (LXRA) mutation found in families with a highly severe and aggressive form of the disease, which disrupts immunomodulatory pathways and cholesterol reverse transport/lipid metabolism.

As part of this vibrant ecosystem, you will have access to numerous opportunities for both foundational and professional development, including high-profile seminar series, career workshops, and multidisciplinary networking events.

Core Responsibilities

• Drive the Science: Lead aspects of the CIHR-funded project investigating mechanisms of neuroinflammation, myelin injury, and repair.
• Execute In Vivo & In Vitro Models: Design and run studies using transgenic mouse models, macrophages, microglia, and CNS-resident immune cells.
• Oversee Cell Culture Studies: Isolate and maintain primary rodent neural (neuronal, glial) and immune cell cultures alongside cell lines.
• Utilize Advanced Techniques: Perform phagocytosis assays, IHC, multicolor spectral flow cytometry, advanced microscopic analyses, live-cell imaging, and molecular analyses (qPCR, siRNA, cDNA delivery).
• Integrate Omics Approaches: Oversee and interpret bulk/single-cell transcriptomic and proteomic data.
• Communicate & Publish: Synthesize complex datasets, author manuscripts, contribute to grants, and present findings at international conferences.
• Mentor & Collaborate: Provide hands-on mentorship to graduate and undergraduate students while collaborating with academic, clinical, and interdisciplinary team partners.

Qualifications

• Education: PhD in neuroscience, immunology, pathology, cell biology, or a related biomedical science field.
• Technical Strengths: Strong hands-on experience with mouse models of demyelinating disease, cell culture methods (primary rodent neural/immune cells), multicolor spectral flow, advanced microscopic analyses, or live-cell imaging.
• Data Expertise: Familiarity or direct experience with single-cell transcriptomics, proteomics, or systems biology datasets.
• Leadership Traits: Proven record of peer-reviewed publications, scientific independence, creativity, and strong organizational skills.
• Team Mindset: Dedicated to scientific rigor, reproducibility, inclusive mentorship, and working across diverse perspectives.

How to Apply

Candidates can review formal requirements and apply directly through the UBC Faculty Careers Portal (Job ID: JR25808-1).

For informal inquiries, please email your application package directly to Dr. Jacqueline Quandt at jquandt@pathology.ubc.ca with the subject line “PDF in Neuroinflammation”. Your submission should include a statement of research interests, a detailed CV specifying your publication contributions, and contact information for 3 professional references.

Review of applications begins immediately on a rolling basis.